CPEB4 Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: CPE binding protein 4 antibody; CPE-binding protein 4 antibody; CPE-BP4 antibody; cpeb4 antibody; CPEB4_HUMAN antibody; Cytoplasmic polyadenylation element binding protein 4 antibody; Cytoplasmic polyadenylation element-binding protein 4 antibody; hCPEB-4 antibody; KIAA1673 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q17RY0 Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5\\\'-UUUUUAU-3\\\') within the mRNA 3\\\'-UTR (PubMed: 24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed: 24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed: 26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed: 22138752). Stimulates proliferation of melanocytes (PubMed: 27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CPEB4 Research Areas: Epigenetics and Nuclear Signaling