CIT Antibody

Size : 100 µL Clone Number: Aliases: CIT antibody; CRIK antibody; KIAA0949 antibody; STK21Citron Rho-interacting kinase antibody; CRIK antibody; EC 2.7.11.1 antibody; Serine/threonine-protein kinase 21 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O14578 Immunogen: Synthesized peptide derived from internal of Human CTRO. Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; IHC: 1: 50-1: 100 Background: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Nagase T., DNA Res. 6: 63-70(1999). Scherer S.E., Nature 440: 346-351(2006). Gruneberg U., J. Cell Biol. 172: 363-372(2006). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CIT Research Areas: Neuroscience;Cell biology;Signal transduction