crp Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: crp antibody; cap antibody; csm antibody; b3357 antibody; JW5702cAMP-activated global transcriptional regulator CRP antibody; Catabolite activator protein antibody; CAP antibody; Catabolite gene activator antibody; cAMP receptor protein antibody; CRP antibody; cAMP regulatory protein antibody Product Type: Polyclonal Antibody Immunogen Species: Escherichia coli (strain K12) UniProt ID: P0ACJ8 Immunogen: Recombinant Escherichia coli cAMP-activated global transcriptional regulator CRP protein (1-210AA) Host: Rabbit Reactivity: Escherichia coli Tested Applications: ELISA Background: A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5\'-AAATGTGATCTAGATCACATTT-3\') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth.Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: crp Research Areas: Others