Cytotoxin 4 Antibody

Size : 50 µg Clone Number: Aliases: antibody; Cytotoxin 4 antibody; CTX-4M antibody; CTX4 antibody; Cardiotoxin A4 antibody; CTX A4 antibody; Cardiotoxin analog IV antibody; CTX IV antibody Product Type: Polyclonal Antibody Immunogen Species: Naja atra (Chinese cobra) UniProt ID: P01443 Immunogen: Recombinant Naja atra Cytotoxin 4 protein (22-81AA) Host: Rabbit Reactivity: Naja atra Tested Applications: ELISA Background: Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: Research Areas: Others