CARF Antibody

Size : 50 µL Clone Number: Aliases: Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 8 antibody; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein antibody; Calcium response factor antibody; Calcium-response factor antibody; Calcium-responsive transcription factor antibody; CaRF antibody; CARTF_HUMAN antibody; Testis development protein NYD SP24 antibody; Testis development protein NYD-SP24 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8N187 Immunogen: Fusion protein of Human CARF Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB; ELISA: 1: 1000-1: 2000, WB: 1: 200-1: 1000 Background: CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CARF Research Areas: Epigenetics and Nuclear Signaling;Cell biology