ACER2 Antibody

Size : 100 µL Clone Number: Aliases: ACER2 antibody; ASAH3L antibody; PP11646 antibody; Alkaline ceramidase 2 antibody; AlkCDase 2 antibody; Alkaline CDase 2 antibody; haCER2 antibody; EC 3.5.1.- antibody; EC 3.5.1.23 antibody; Acylsphingosine deacylase 3-like antibody; N-acylsphingosine amidohydrolase 3-like antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q5QJU3 Immunogen: Synthesized peptide derived from internal of Human ASAH3L. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18: 1)-, C(20: 1)-, C(20: 4)-ceramide > D-erythro-C(16: 0)-, C(18: 0), C(20: 0)-ceramide > D-erythro-C(24: 1)-ceramide > D-erythro-C(12: 0)-ceramide, D-erythro-C(14: 0)-ceramides > D-erythro-C(24: 0)-ceramide > D-erythro-C(6: 0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. Xu R., FASEB J. 20: 1813-1825(2006) [PubMed: 16940153]. Wan D.,Proc. Natl. Acad. Sci. U.S.A. 101: 15724-15729(2004) [PubMed: 15498874]. Humphray S.J., Nature 429: 369-374(2004) [PubMed: 15164053]. Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ACER2 Research Areas: Metabolism;Signal transduction