CSK Antibody

Size : 100 µL Clone Number: Aliases: C SRC antibody; C SRC kinase antibody; C src Tyrosine Kinase antibody; C-SRC kinase antibody; c-src tyrosine kinase antibody; Csk A antibody; CSK antibody; CSK_HUMAN antibody; CYTOPLASMIC TYROSINE KINASE antibody; EC 2.7.10.2 antibody; MGC112926 antibody; MGC117393 antibody; MGC154049 antibody; P60 Src antibody; Protein tyrosine kinase CYL antibody; Protein-tyrosine kinase CYL antibody; Proto oncogene tyrosine protein kinase antibody; Tyrosine protein kinase CSK antibody; Tyrosine-protein kinase CSK antibody; zgc: 154049 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P41240 Immunogen: Synthesized peptide derived from internal of Human CSK. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IF; WB: 1: 500-1: 3000, IF: 1: 100-1: 500 Background: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. Partanen J., Oncogene 6: 2013-2018(1991). Braeuninger A., Proc. Natl. Acad. Sci. U.S.A. 88: 10411-10415(1991). Brauninger A., Gene 110: 205-211(1992). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CSK Research Areas: Signal transduction