CDK5 Antibody

Size : 50 µL Clone Number: Aliases: Cdk 5 antibody; Cdk5 antibody; CDK5_HUMAN antibody; Cell division protein kinase 5 antibody; Crk6 antibody; Cyclin dependent kinase 5 antibody; Cyclin-dependent kinase 5 antibody; Protein kinase CDK5 splicing antibody; PSSALRE antibody; Serine threonine protein kinase PSSALRE antibody; Serine/threonine-protein kinase PSSALRE antibody; Tau protein kinase II catalytic subunit antibody; TPKII catalytic subunit antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q00535 Immunogen: Fusion protein of Human CDK5 Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IHC; ELISA: 1: 1000-1: 2000, WB: 1: 200-1: 1000, IHC: 1: 10-1: 50 Background: Cell division protein kinase 5 is an enzyme that in humans is encoded by the CDK5 gene. The protein encoded by this gene is part of the cyclin-dependent kinase family. CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1 or CDK5R2. Cdk5 is involved in the processes of neuronal maturation and migration, phosphorylating the key intracellular adaptor of the reelin signaling chain. Experiments performed on mice lacking p35, a necessary activator of cdk5 in early brain development, showed that the normal layering of neurons was reversed in the cortex. This disrupted lamination again implicated cdk5 in neuronal migration and plasticity. Cdk5 is also involved in the regulation of synaptic vesicle exocytosis via phosphorylation of munc-18. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDK5 Research Areas: Neuroscience?Cancer;Cell biology;Metabolism