CYP2D6 Antibody

Size : 50 µL Clone Number: Aliases: Cholesterol 25-hydroxylase antibody; CP2D6_HUMAN antibody; CPD6 antibody; CYP2D antibody; CYP2D6 antibody; CYP2D7AP antibody; CYP2D7BP antibody; CYP2D7P2 antibody; CYP2D8P2 antibody; CYP2DL1 antibody; CYPIID6 antibody; Cytochrome P450 2D6 antibody; Cytochrome P450 DB1 antibody; Cytochrome P450 family 2 subfamily D member 6 antibody; Cytochrome P450 family 2 subfamily D polypeptide 6 antibody; Cytochrome P450-DB1 antibody; Debrisoquine 4 hydroxylase antibody; Debrisoquine 4-hydroxylase antibody; Flavoprotein linked monooxygenase antibody; Microsomal monooxygenase antibody; P450 DB1 antibody; P450C2D antibody; P450DB1 antibody; Xenobiotic monooxygenase antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P10635 Immunogen: Synthetic peptide of Human CYP2D6 Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; ELISA: 1: 2000-1: 5000, IHC: 1: 50-1: 200 Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CYP2D6 Research Areas: Cancer Cardiovascular;Metabolism;Signal transduction