CDH23 Antibody

Size : 100 µL Clone Number: Aliases: CDH23 antibody; KIAA1774 antibody; KIAA1812 antibody; UNQ1894/PRO4340Cadherin-23 antibody; Otocadherin antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9H251 Immunogen: Synthesized peptide derived from internal of Human CDH23. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, IF; IF: 1: 100-1: 500 Background: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Bolz H., Nat. Genet. 27: 108-112(2001). Clark H.F., Genome Res. 13: 2265-2270(2003). Bork J.M., Am. J. Hum. Genet. 68: 26-37(2001). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDH23 Research Areas: Neuroscience;Signal transduction