CDK8 Antibody

Size : 50 µL Clone Number: Aliases: cdk8 antibody; CDK8 protein kinase antibody; CDK8_HUMAN antibody; Cell Division Kinase 8 antibody; Cell division protein kinase 8 antibody; Cyclin Dependent kinase 8 antibody; Cyclin-dependent kinase 8 antibody; K35 antibody; Mediator complex subunit cdk8 antibody; Mediator of RNA polymerase II transcription subunit cdk8 antibody; Protein kinase K35 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P49336 Immunogen: Synthetic peptide of Human CDK8 Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, IHC; ELISA: 1: 2000-1: 5000, IHC: 1: 25-1: 100 Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDK8 Research Areas: Epigenetics and Nuclear Signaling;Cell biology