CMKLR1 Antibody

Size : 100 µL Clone Number: Aliases: CHEMERINR antibody; Chemokine like receptor 1 antibody; Chemokine-like receptor 1 antibody; CHEMR23 antibody; CMKLR1 antibody; CML1_HUMAN antibody; DEZ antibody; G protein coupled receptor ChemR23 antibody; G protein coupled receptor DEZ antibody; G-protein coupled receptor ChemR23 antibody; G-protein coupled receptor DEZ antibody; Orphan G protein coupled receptor antibody; Orphan G protein coupled receptor Dez antibody; Resolvin E1 receptor antibody; RVER1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q99788 Immunogen: Synthesized peptide derived from internal of Human CMKLR1. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Methner A., Biochem. Biophys. Res. Commun. 233: 336-342(1997). Samson M., Eur. J. Immunol. 28: 1689-1700(1998). Hillman R.T., Genome Biol. 5: RESEARCH008.1-RESEARCH008.16(2004). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CMKLR1 Research Areas: Cell biology;Signal transduction