CABLES1 Antibody

Size : 100 µL Clone Number: Aliases: CABL1_HUMAN antibody; CABLES antibody; Cables1 antibody; Cdk5 and Abl enzyme substrate 1 antibody; CDK5 and ABL1 enzyme substrate 1 antibody; FLJ35924 antibody; HsT2563 antibody; IK3 1 antibody; Ik3-1 antibody; Interactor with CDK3 1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8TDN4 Immunogen: Synthesized peptide derived from internal of Human Ik3-1. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity. Ota T., Nat. Genet. 36: 40-45(2004). Nusbaum C., Nature 437: 551-555(2005). Wu C.-L., Cancer Res. 61: 7325-7332(2001). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CABLES1 Research Areas: Cell biology