COL4A2 Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: Canstatin antibody; CO4A2_HUMAN antibody; COL4A 2 antibody; Col4a2 antibody; Collagen alpha 2(IV) chain antibody; Collagen; type IV; alpha 2 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P08572 Immunogen: Recombinant Human Collagen alpha-2(IV) chain protein (1493-1712AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a \\\'chicken-wire\\\' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: COL4A2 Research Areas: Cardiovascular; Signal transduction