CRY1 Antibody

Size : 100 µL Clone Number: Aliases: Cry1 antibody; CRY1_HUMAN antibody; Cryptochrome 1 (photolyase like) antibody; Cryptochrome 1 antibody; Cryptochrome-1 antibody; PHLL1 antibody; Photolyase 1 antibody; Photolyase-like antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q16526 Immunogen: Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1. Host: Rabbit Reactivity: Mouse Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N,et al. (2010) J Pharmacol Sci.113(3): 234-45. Fonseca F,et al. (2010) Mol Diagn Ther.14(3): 171-8. Stratmann M,et al.(2010) Genes Dev.24(12): 1317-28. Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjugate: Non-conjugated Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CRY1 Research Areas: Neuroscience;Cardiovascular