CCAR2 Antibody

Size : 100 µL Clone Number: Aliases: CCAR2 antibody; DBC1 antibody; KIAA1967Cell cycle and apoptosis regulator protein 2 antibody; Cell division cycle and apoptosis regulator protein 2 antibody; DBIRD complex subunit KIAA1967 antibody; Deleted in breast cancer gene 1 protein antibody; DBC-1 antibody; DBC.1 antibody; NET35 antibody; p30 DBC antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8N163 Immunogen: Synthesized peptide derived from internal of Human KIAA1967. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Nagase T., DNA Res. 8: 319-327(2001). Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99: 13647-13652(2002). Olsen J.V., Cell 127: 635-648(2006). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CCAR2 Research Areas: Epigenetics and Nuclear Signaling