CCNA1 Antibody

Size : 50 µL Clone Number: Aliases: CCN A1 antibody; CCNA 1 antibody; Ccna1 antibody; CCNA1_HUMAN antibody; Cyclin-A1 antibody; CyclinA1 antibody; G2/mitotic specific cyclin A1 antibody; MGC132235 antibody; MGC159139 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P78396 Immunogen: Fusion protein of Human CCNA1 Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, IHC; ELISA: 1: 2000-1: 5000, IHC: 1: 20-1: 100 Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CCNA1 Research Areas: Others