CBR1 Antibody

Size : 100 µL Clone Number: Aliases: 15 hydroxyprostaglandin dehydrogenase [NADP+] antibody; 15-hydroxyprostaglandin dehydrogenase [NADP+] antibody; Carbonyl reductase [NADPH] 1 antibody; Carbonyl Reductase 1 antibody; CBR 1 antibody; CBR1 antibody; CBR1_HUMAN antibody; CRN antibody; NADPH dependent carbonyl reductase 1 antibody; NADPH-dependent carbonyl reductase 1 antibody; Prostaglandin 9 ketoreductase antibody; Prostaglandin 9-ketoreductase antibody; Prostaglandin E(2) 9 reductase antibody; Prostaglandin-E(2) 9-reductase antibody; SDR21C1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P16152 Immunogen: Synthesized peptide derived from internal of Human CBR1. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100 Background: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Wermuth B., J. Biol. Chem. 263: 16185-16188(1988). Forrest G.L., Biochim. Biophys. Acta 1048: 149-155(1990). Forrest G.L., Mol. Pharmacol. 40: 502-507(1991). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBR1 Research Areas: Cancer;Cell biology;Metabolism;Signal transduction