CLDN8 Antibody

Size : 50 µL Clone Number: Aliases: Claudin 8 antibody; Claudin-8 antibody; CLD8_HUMAN antibody; Cldn8 antibody; Epididymis secretory protein Li 79 antibody; HEL S 79 antibody; OTTHUMP00000101915 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P56748 Immunogen: Synthetic peptide of Human CLDN8 Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; ELISA: 1: 2000-1: 10000, IHC: 1: 100-1: 300 Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CLDN8 Research Areas: Signal transduction