ADAM15 Antibody

Size : 50 µg Clone Number: Aliases: A disintegrin and metalloproteinase domain 15 (metargidin) antibody; A disintegrin and metalloproteinase domain 15 antibody; ADA15_HUMAN antibody; ADAM 15 antibody; ADAM metallopeptidase domain 15 antibody; Adam15 antibody; and cysteine-rich protein 15 antibody; Disintegrin and metalloproteinase domain-containing protein 15 antibody; disintegrin-like antibody; EC 3.4.24. antibody; MDC 15 antibody; MDC-15 antibody; MDC15 antibody; Metalloprotease RGD disintegrin protein antibody; Metalloproteinase like disintegrin like and cysteine rich protein 15 antibody; Metalloproteinase-like antibody; Metargidin antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13444 Immunogen: Recombinant Human Disintegrin and metalloproteinase domain-containing protein 15 protein (207-452AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ADAM15 Research Areas: Cancer; Cell biology; Signal transduction