DDX5 Antibody

Size : 50 µL Clone Number: Aliases: ATP dependent RNA helicase DDX5 antibody; DDX 5 antibody; Ddx5 antibody; DDX5_HUMAN antibody; DEAD (Asp Glu Ala Asp) box helicase 5 antibody; DEAD (Asp Glu Ala Asp) box polypeptide 5 antibody; DEAD box 5 antibody; DEAD box protein 5 antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase; 68kD) antibody; G17P1 antibody; HELR antibody; HLR1 antibody; HUMP68 antibody; P68 antibody; p68 RNA helicase antibody; Probable ATP dependent RNA helicase DDX5 antibody; Probable ATP-dependent RNA helicase DDX5 antibody; RNA helicase p68 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P17844 Immunogen: Recombinant Human Probable ATP-dependent RNA helicase DDX5 protein (1-290AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 500-1: 2000, IHC: 1: 20-1: 200 Background: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3\\\' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: DDX5 Research Areas: Epigenetics and Nuclear Signaling