CYP1B1 Antibody

Size : 100 µL Clone Number: Aliases: Aryl hydrocarbon hydroxylase antibody; CP1B antibody; CP1B1_HUMAN antibody; Cyp1b1 antibody; CYPIB1 antibody; Cytochrome P450 1B1 antibody; Cytochrome P450 family 1 subfamily B polypeptide 1 antibody; Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody; Flavoprotein linked monooxygenase antibody; GLC3A antibody; Microsomal monooxygenase antibody; P4501B1 antibody; Xenobiotic monooxygenase antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q16678 Immunogen: Recombinant protein of Human CYP1B1 Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 2000, IHC: 1: 50-1: 200 Background: Cytochrome P450 1B1 (CYP1B1) is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function. Clonality: Polyclonal Isotype: IgG Purification Method: Affinity purification Conjugate: Non-conjugated Buffer: Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CYP1B1 Research Areas: Neuroscience;Cardiovascular;Metabolism;Signal transduction