CELF2 Antibody

Size : 50 µg Clone Number: Aliases: Bruno-like protein 3 antibody; BRUNOL3 antibody; Cardiac elav type RNA binding protein antibody; CELF-2 antibody; celf2 antibody; CELF2_HUMAN antibody; CUG BP2 antibody; CUG triplet repeat RNA-binding protein 2 antibody; CUG-BP- and ETR-3-like factor 2 antibody; CUG-BP2 antibody; CUGBP Elav like family member 2 antibody; CUGBP Elav-like family member 2 antibody; CUGBP2 antibody; dJ323N1.1 antibody; elav type RNA binding protein antibody; ELAV-type RNA-binding protein 3 antibody; ETR 3 antibody; ETR-3 antibody; ETR3 antibody; HGNC: 2550 antibody; hNAPOR antibody; NAPOR 2 antibody; NAPOR antibody; Neuroblastoma apoptosis-related RNA-binding protein antibody; Neuroplastoma apoptosis related RNA binding protein 3 antibody; RNA binding protein BRUNOL3 antibody; RNA-binding protein BRUNOL-3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O95319 Immunogen: Recombinant Human CUGBP Elav-like family member 2 protein (291-381AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 500-1: 1000, IF: 1: 50-1: 200 Background: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3\\\'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3\\\'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CELF2 Research Areas: Epigenetics and Nuclear Signaling