CSNK1G2 Antibody

Size : 50 µL Clone Number: Aliases: Casein kinase 1; gamma 2 antibody; Casein kinase I isoform gamma 2 antibody; Casein kinase I isoform gamma-2 antibody; CK1g2 antibody; CKI gamma 2 antibody; CKI-gamma 2 antibody; CSNK1G 2 antibody; Csnk1g2 antibody; KC1G2_HUMAN antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P78368 Immunogen: Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA) Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC, IP; Recommended dilution: WB: 1: 1000-1: 5000, IHC: 1: 20-1: 200, IP: 1: 200-1: 2000 Background: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CSNK1G2 Research Areas: Cancer; Metabolism; Signal transduction; Stem cells