COPS2 Antibody

Size : 50 µL Clone Number: Aliases: ALIEN antibody; Alien Drosophila himolog of antibody; Alien homolog antibody; COP 9 antibody; COP9 antibody; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody; COP9 constitutive photomorphogenic homolog subunit 2 antibody; COP9 signalosome complex subunit 2 antibody; COPS 2 antibody; Cops2 antibody; CSN2 antibody; CSN2_HUMAN antibody; JAB1 containing signalosome subunit 2 antibody; JAB1-containing signalosome subunit 2 antibody; SGN 2 antibody; SGN2 antibody; Signalosome subunit 2 antibody; Thyroid Hormone Receptor Interactor15 antibody; Thyroid Hormone Receptor Interactor 15 antibody; Thyroid receptor-interacting protein 15 antibody; TR-interacting protein 15 antibody; TRIP 15 antibody; TRIP-15 antibody; TRIP15 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P61201 Immunogen: Recombinant Human COP9 signalosome complex subunit 2 protein (1-310AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: COPS2 Research Areas: Epigenetics and Nuclear Signaling; Signal transduction