CENPA (Ab-7) Antibody

Size : 50 µL Clone Number: Aliases: CENP A antibody; CENP-A antibody; cenpa antibody; CENPA_HUMAN antibody; Centromere autoantigen A antibody; Centromere protein A 17kDa antibody; Centromere protein A antibody; Histone H3 like centromeric protein A antibody; Histone H3-like centromeric protein A antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P49450 Immunogen: Peptide sequence around site of Ser (7) derived from Human Histone H3-like centromeric protein A Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 10-1: 100 Background: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed: 7962047, PubMed: 9024683, PubMed: 11756469, PubMed: 14667408, PubMed: 15702419, PubMed: 15475964, PubMed: 15282608, PubMed: 17651496, PubMed: 19114591, PubMed: 27499292, PubMed: 20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed: 18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed: 27499292, PubMed: 26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed: 15475964, PubMed: 15282608, PubMed: 26878239, PubMed: 20739937, PubMed: 21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed: 11756469, PubMed: 14667408, PubMed: 18072184, PubMed: 23818633, PubMed: 25556658, PubMed: 27499292). Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CENPA Research Areas: Epigenetics and Nuclear Signaling