CCND3 Antibody

Size : 50 µL Clone Number: Aliases: CCND 3 antibody; Ccnd3 antibody; CCND3_HUMAN antibody; CyclinD3 antibody; D3 type cyclin antibody; G1 S specific cyclin D3 antibody; G1/S specific cyclin D3 antibody; G1/S-specific cyclin-D3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P30281 Immunogen: Recombinant Human G1/S-specific cyclin-D3 protein (1-292AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC, IF, IP; Recommended dilution: WB: 1: 500-1: 2000, IHC: 1: 20-1: 200, IF: 1: 50-1: 200, IP: 1: 200-1: 2000 Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CCND3 Research Areas: Others