CBFA2T3 Antibody

Size : 50 µg Clone Number: Aliases: Cbfa2t3 antibody; Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody; ETO2 antibody; hMTG16 antibody; hMTG16a antibody; hMTG16b antibody; MTG16 antibody; MTG16_HUMAN antibody; MTG8 related gene 2 antibody; MTG8 related protein MTG16a antibody; MTG8 related protein MTG16b antibody; MTG8-related protein 2 antibody; MTGR2 antibody; Myeloid translocation gene 8 and 16b antibody; Myeloid translocation gene on chromosome 16 protein antibody; Protein CBFA2T3 antibody; Zinc finger MYND domain-containing protein 4 antibody; ZMYND4 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O75081 Immunogen: Recombinant Human Protein CBFA2T3 protein (39-159AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 200-1: 500 Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed: 12559562, PubMed: 15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed: 23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed: 25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed: 23840896, PubMed: 25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed: 15231665). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBFA2T3 Research Areas: Epigenetics and Nuclear Signaling; Cancer