CBFA2T2 Antibody

Size : 50 µL Clone Number: Aliases: AML1 MTG8 antibody; cbfa2t2 antibody; Core binding factor runt domain alpha subunit 2 translocated to 2 antibody; core-binding factor; runt domain; alpha subunit 2 antibody; DKFZp313F2116 antibody; EHT antibody; ETO homolog on chromosome 20 antibody; ETO homologous on chromosome 20 antibody; MTG 8 like protein antibody; MTG 8 related protein 1 antibody; MTG8 like protein antibody; MTG8 related protein 1 antibody; MTG8-like protein antibody; MTG8-related protein 1 antibody; MTG8R_HUMAN antibody; MTGR 1 antibody; Myeloid translocation gene related protein 1 antibody; Myeloid translocation related protein 1 antibody; Myeloid translocation-related protein 1 antibody; p85 antibody; Protein CBFA2T2 antibody; ZMYND 3 antibody; ZMYND3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O43439 Immunogen: Recombinant Human Protein CBFA2T2 protein (325-604AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 1000-1: 5000, IHC: 1: 20-1: 200 Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed: 12559562, PubMed: 15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed: 23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBFA2T2 Research Areas: Tags & Cell Markers