BVES Antibody

Size : 50 µL Clone Number: Aliases: Blood vessel epicardial substance antibody; Bves antibody; hBVES antibody; MGC42413 antibody; POP 1 antibody; POP1 antibody; POPD1_HUMAN antibody; POPDC 1 antibody; POPDC1 antibody; Popeye domain containing 1 antibody; Popeye domain containing protein 1 antibody; Popeye domain-containing protein 1 antibody; Popeye protein 1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8NE79 Immunogen: Recombinant Human Blood vessel epicardial substance protein (241-360AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IF; Recommended dilution: IF: 1: 50-1: 200 Background: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed: 16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed: 26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: BVES Research Areas: Signal transduction