BAG3 Antibody,HRP conjugated

Size : 50 µL Clone Number: Aliases: BAG 3 antibody; BAG family molecular chaperone regulator 3 antibody; BAG-3 antibody; Bag3 antibody; BAG3_HUMAN antibody; Bcl 2 binding protein antibody; Bcl-2-associated athanogene 3 antibody; Bcl-2-binding protein Bis antibody; BCL2 associated athanogene 3 antibody; BCL2 binding athanogene 3 antibody; BIS antibody; CAIR 1 antibody; Docking protein CAIR 1 antibody; Docking protein CAIR-1 antibody; MFM6 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O95817 Immunogen: Recombinant Human BAG family molecular chaperone regulator 3 protein (220-420AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed: 9873016, PubMed: 27474739). Has anti-apoptotic activity (PubMed: 10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed: 26159920). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Antigen Affinity purified & Affinity purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: BAG3 Research Areas: Signal Transduction