A2ML1 Antibody

Size : 50 µg Clone Number: Aliases: A2ML1 antibody; CPAMD9Alpha-2-macroglobulin-like protein 1 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: A8K2U0 Immunogen: Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 20-1: 200 Background: Is able to inhibit all four classes of proteinases by a unique \\\'trapping\\\' mechanism. This protein has a peptide stretch, called the \\\'bait region\\\' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: A2ML1 Research Areas: Cell biology; Immunology