CD79A Monoclonal Antibody

Size : 50 µL Clone Number: Aliases: B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a), CD79A, IGA MB1 Product Type: Monoclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P11912 Immunogen: Synthesized peptide derived from human CD79a Host: Mouse Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. Clonality: Monoclonal Isotype: IgG2a, Kappa Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. Conjugate: Non-conjugated Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CD79A Research Areas: Immunology