CD8A Monoclonal Antibody,Biotin Conjugated

Size : 100 µL Clone Number: Aliases: Product Type: Monoclonal Antibody Immunogen Species: Human UniProt ID: P01732 Immunogen: Recombinant Protein Host: Mouse Reactivity: Human Tested Applications: ELISA,IF,FC;Recommended dilution: IF: 1: 100-1: 200 Background: COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.* Ratio of CD4 and CD8 is important for monitor of HIV infection.1. Engleman EG et al. (1981) J Exp Med 153: 193-198.2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.4. Bikah G. et al. (1996). Science 274: 1906. Clonality: Monoclonal Isotype: IgG1 Purification Method: Affinity purified Conjugate: Non-conjugated Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CD8A Research Areas: Immunology