CD14 Monoclonal Antibody

Size : 50 µL Clone Number: 14G1F3 Aliases: Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form], CD14 Product Type: Monoclonal Antibody Immunogen Species: Human UniProt ID: P08571 Immunogen: Recombinant Human Monocyte differentiation antigen CD14 protein (20-345AA) Host: Mouse Reactivity: Human, Mouse, Rabbit Tested Applications: ELISA, WB, IHC, IF, FC; Recommended dilution: WB: 1: 1000-1: 5000, IHC: 1: 50-1: 200, IF: 1: 50-1: 200 Background: Coreceptor for bacterial lipopolysaccharide (PubMed: 1698311, PubMed: 23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed: 20133493, PubMed: 23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed: 8612135). Acts as a coreceptor for TLR2: TLR6 heterodimer in response to diacylated lipopeptides and for TLR2: TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed: 16880211). Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PubMed: 23880187). Clonality: Monoclonal Isotype: IgG1 Purification Method: 95%, Protein A purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CD14 Research Areas: Immunology; Stem cells