APP Monoclonal Antibody

Size : 50 µg Clone Number: 5A11E5 Aliases: Amyloid Beta (A4) Precursor Protein, ABPP, APP, Beta-Amyloid Peptide Product Type: Monoclonal Antibody Immunogen Species: Human UniProt ID: P05067 Immunogen: Recombinant Human APP Protein Host: Mouse Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 50-1: 500, IF: 1: 50-1: 200 Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. Clonality: Monoclonal Isotype: Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: APP Research Areas: Neuroscience